Metyrosine

Names

[ CAS No. ]:
672-87-7

[ Name ]:
Metyrosine

[Synonym ]:
MFCD00064201
(S)-alpha-Methyltyrosine
α-METHYL-L-P-TYROSINE
alpha-methyl-L-tyrosine
EINECS 211-599-5

Biological Activity

[Description]:

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> COX

[In Vitro]

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

[In Vivo]

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1]. Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2] Dosage: 50, 100 or 200 mg/kg Administration: I.p. Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).

[References]

[1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119.

[2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336.

Chemical & Physical Properties

[ Density]:
1.283g/cm3

[ Boiling Point ]:
383.7ºC at 760 mmHg

[ Melting Point ]:
320-340°C dec.

[ Molecular Formula ]:
C₁₀H₁₃NO₃

[ Molecular Weight ]:
195.21500

[ Flash Point ]:
185.9ºC

[ Exact Mass ]:
195.09000

[ PSA ]:
83.55000

[ LogP ]:
1.43700

[ Index of Refraction ]:
1.599

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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