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pralidoxime

Names

[ CAS No. ]:
6735-59-7

[ Name ]:
pralidoxime

[Synonym ]:
Conthrathion
2-(hydroxyimino-methyl)-1-methyl-pyridinium
PRALIDOXIME
N-Methyl-2-pyridyl-aldoxim-hydroxid
2-PAM
2-(Hydroxyiminomethyl)-1-methylpyridinium
2-(hydroximinomethyl)-1-methylpyridinium cation
(2-Hydroxyimino-methyl)-1-methyl-pyridinium

Biological Activity

[Description]:

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Acetylcholinesterase


[In Vivo]

Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3]. Animal Model: F1B6D2 mice (male, administered subcutaneously diethylparaoxon)[3] Dosage: 10, 50, 100, and 150 mg/kg Administration: Intramuscular administration, once Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.

[References]

[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141.

[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111.

[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.

Chemical & Physical Properties

[ Molecular Formula ]:
C7H9N2O+

[ Molecular Weight ]:
137.15900

[ Exact Mass ]:
137.07100

[ PSA ]:
36.47000

[ LogP ]:
0.31920

Related Compounds