Bethanechol

Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.Target: muscarinic receptorHyoscine butylbromide concentration dependently reduced muscle contractions, calcium mobilization, and epithelial secretion induced by the muscarinic agonist bethanechol with IC50 values of 429, 121, and 224 nmol L(-1), respectively.[2] Bethanechol presentes significantly improve of salivary parameters. Bethanechol is effective in decreasing the salivary gland damage.[3] Cerebral malakoplakia is a very rare chronic inflammatory disease. Treatment with antibiotic Bethanechol improves symptoms in association with a decrease in the abnormal calcification and enhancement.[4]

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Neurological Disease

[1]. Bethanechol

[2]. Krueger D, et al. Effect of hyoscine butylbromide (Buscopan) on cholinergic pathways in the human intestine. Neurogastroenterol Motil. 2013 Aug;25(8):e530-9.

[3]. Jaguar GC, et al. Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients. Radiother Oncol. 2015 May;115(2):253-256.

[4]. Fudaba H, et al. An adult case of cerebral malakoplakia successfully cured by treatment with antibiotics, bethanechol and ascorbic acid. J Neurol Sci. 2014 Jul 15;342(1-2):192-196.

Carbachol | Darifenacin HBr | Arecoline hydrobromide | Pirenzepine, Dihydrochloride | Glycopyrrolate | Imidafenacin | Benztropine Mesylate | Xanomeline oxalate | Batefenterol | Bethanechol chloride | Cevimeline hydrochloride hemihydrate | Otilonium Bromide | solifenacin | VU0467154 | Anisodamine

MOLECULAR FORMULA :

C7-H17-N2-O2

MOLECULAR WEIGHT :

161.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

64 mg/kg/30D-I

TOXIC EFFECTS :

Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,279,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5587 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 340 (estimated) No. of Female Employees: 180 (estimated)