triacetate lactone

Names

[ CAS No. ]:
675-10-5

[ Name ]:
triacetate lactone

[Synonym ]:
2H-Pyran-2-one, 4-hydroxy-6-methyl-
triacetate lactone
EINECS 211-619-2
6-methyl-4-hydroxypyran-2-one
Triacetic acid lactone
6-METHYL-4-HYDROXY-2-PYRANONE
MFCD00006641
4-Hydroxy-6-methyl-2-pyrone
6-Methyl-4-hydroxy-2-pyrones
4-Hydroxy-6-methyl-2-oxo-2H-pyran
6-METHYL-4-HYDROXY-2-PYRONE
6-methyl-4-hydroxypyron-(2)
Hydroxy-6-methyl-2-pyrone,4
4-Hydroxy-6-methyl-2H-pyran-2-one
4-Hydroxy-6-methylpyran-2-one
4-hydroxy-6-methyl-pyran-2-one
AURORA KA-5368

Biological Activity

[Description]:

4-Hydroxy-6-methyl-2-pyrone is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
239.1±40.0 °C at 760 mmHg

[ Melting Point ]:
188-190 °C (dec.)(lit.)

[ Molecular Formula ]:
C₆H₆O₃

[ Molecular Weight ]:
126.11

[ Flash Point ]:
108.7±20.1 °C

[ Exact Mass ]:
126.031693

[ PSA ]:
50.44000

[ LogP ]:
0.15

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.561

[ Water Solubility ]:
8.60 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ1000000

CHEMICAL NAME :: 2H-Pyran-2-one, 4-hydroxy-6-methyl-

CAS REGISTRY NUMBER :: 675-10-5

BEILSTEIN REFERENCE NO. :: 0113815

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: T6OVJ DQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,126,1960

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UQ1000000

[ HS Code ]:
2932999099

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.

Biochem. J. 288 ( Pt 3) , 839-46, (1992)

6-Methylsalicylic acid synthase has been isolated in homogeneous form from Penicillium patulum grown in liquid culture from a spore inoculum. The enzyme is highly susceptible to proteolytic degradatio...

Microbial synthesis of triacetic acid lactone.

Biotechnol. Bioeng. 93(4) , 727-36, (2006)

Native g2ps1-encoded 2-pyrone synthase (2-PS) from Gerbera hybrida, a mutant Brevibacterium ammoniagenes fatty acid synthase B (FAS-B) and two different mutants of Penicillium patulum 6-methylsalycili...

Rational pathway engineering of type I fatty acid synthase allows the biosynthesis of triacetic acid lactone from D-glucose in vivo.

J. Am. Chem. Soc. 126(14) , 4534-5, (2004)

Metabolic pathway engineering is a powerful tool to synthesize structurally diverse and complex chemicals via genetic manipulation of multistep catalytic systems involved in cell metabolism. Here, we ...