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PG 01037 dihydrochloride

Names

[ CAS No. ]:
675599-62-9

[ Name ]:
PG 01037 dihydrochloride

[Synonym ]:
Benzamide, N-[(2E)-4-[4-(2,3-dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridinyl)-, hydrochloride (1:2)
N-{(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl}-4-(2-pyridinyl)benzamide dihydrochloride

Biological Activity

[Description]:

PG01037 (dihydrochloride) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

D3 Receptor:0.7 nM (Ki)


[References]

[1]. Grundt P, et al. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. J Med Chem. 2005 Feb 10;48(3):839-48.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28Cl4N4O

[ Molecular Weight ]:
554.339

[ Exact Mass ]:
552.101746

[ Storage condition ]:
2-8°C

Related Compounds