<Suppliers Price>

Bevenopran

Names

[ CAS No. ]:
676500-67-7

[ Name ]:
Bevenopran

[Synonym ]:
UNII-IC58Q2EHPJ
CB5945
Bevenopran

Biological Activity

[Description]:

Bevenopran is a peripheral μ-opioid receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Inflammation/Immunology

[Target]

μ-opioid receptor[1]


[In Vivo]

Bevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD)[1]. Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively[1].

[References]

[1]. Diego L, et al. Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56.

[2]. Siemens W, et al. Advances in pharmacotherapy for opioid-induced constipation - a systematic review. Expert Opin Pharmacother. 2015 Mar;16(4):515-32.


[Related Small Molecules]

PZM-21 | Loperamide hydrochloride | Oliceridine hydrochloride | ADL5859 HCl | JDTic (dihydrochloride) | Naltrindole hydrochloride | LY-2456302 | JTC-801 | Matrine | Met-Enkephalin acetate salt | Cebranopadol | Leu-Enkephalin | DAMGO | Sinomenine HCl | SR17018

Chemical & Physical Properties

[ Molecular Formula ]:
C20H26N4O4

[ Molecular Weight ]:
386.44500

[ Exact Mass ]:
386.19500

[ PSA ]:
109.58000

[ LogP ]:
3.55780

[ Storage condition ]:
2-8℃

Related Compounds