9-Hydroxycamptothecin

Names

[ Name ]:
9-Hydroxycamptothecin

[Synonym ]:
10-Hydroxycamptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-
hydroxycamtothecine
Camptothecin, 10-hydroxy
9-hydroxy-20(S)-camptothecin
10-hydroxy-Camptothecin
9-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g] chromene-5,10-dione
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
3,4-dihydro-9-hydroxy-2,2-dimethyl-2H-benzo[g]chromene-5,10

Biological Activity

[Description]:

9-Hydroxycamptothecin (9-Hydroxycamptothecine) is a Camptothecin derivative with anticancer activities extracted from patent WO1999001456A1, compound 23c[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Dennis P. Curran, et al. Synthesis of and intermediates for camptothecins. WO1999001456A1.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
820.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₆N₂O₅

[ Molecular Weight ]:
364.351

[ Flash Point ]:
450.1±34.3 °C

[ Exact Mass ]:
364.105927

[ PSA ]:
101.65000

[ LogP ]:
1.32

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.777

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%