Bromo-PEG5-bromide

Names

[ CAS No. ]:
67705-77-5

[ Name ]:
Bromo-PEG5-bromide

[Synonym ]:
1-[2-(2-bromoethoxy)ethoxy]-2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethane

Biological Activity

[Description]:

Bromo-PEG5-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.433g/cm3

[ Boiling Point ]:
413.195ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₄Br₂O₅

[ Molecular Weight ]:
408.12400

[ Flash Point ]:
170.724ºC

[ Exact Mass ]:
405.99900

[ PSA ]:
46.15000

[ LogP ]:
1.85920

[ Index of Refraction ]:
1.486

Bromo-PEG5-bromide

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds