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SM-324405

Names

[ CAS No. ]:
677773-91-0

[ Name ]:
SM-324405

[Synonym ]:
Methyl {3-[(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl]phenyl}acetate
MFCD30182295
Benzeneacetic acid, 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-, methyl ester

Biological Activity

[Description]:

SM-324405 is a TLR7 agonist, with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Inflammation/Immunology

[In Vitro]

SM-324405 is a novel candidate for immunotherapy of allergic diseases[1].

[In Vivo]

SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically[1]. SM-324405 exhibits t1/2 of 2.6 min in human plasma[2].

[References]

[1]. Ayumu Kurimoto, et al. Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J Med Chem. 2010 Apr 8;53(7):2964-72.

[2]. M Biffen, et al. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br J Pharmacol. 2012 May;166(2):573-86.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
654.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H23N5O4

[ Molecular Weight ]:
385.42

[ Flash Point ]:
349.3±34.3 °C

[ Exact Mass ]:
385.175018

[ LogP ]:
1.55

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.645

Related Compounds