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HO-PEG16-OH

Names

[ CAS No. ]:
6812-36-8

[ Name ]:
HO-PEG16-OH

[Synonym ]:
hexadecaethylene glycol
EINECS 229-886-9
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-Pentadecaoxaheptatetracontane-1,47-diol

Biological Activity

[Description]:

HO-PEG16-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.116g/cm3

[ Boiling Point ]:
714.7ºC at 760 mmHg

[ Molecular Formula ]:
C32H66O17

[ Molecular Weight ]:
722.85600

[ Flash Point ]:
386.1ºC

[ Exact Mass ]:
722.43000

[ PSA ]:
178.91000

[ Index of Refraction ]:
1.466

Related Compounds