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Micheliolide

Names

[ CAS No. ]:
68370-47-8

[ Name ]:
Micheliolide

[Synonym ]:
Azuleno[4,5-b]furan-2(3H)-one, 3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-, (3aS,9R,9aS,9bS)-
(3aS,9R,9aS,9bS)-9-Hydroxy-6,9-dimethyl-3-methylene-3a,4,5,7,8,9,9a,9b-octahydroazuleno[4,5-b]furan-2(3H)-one
Mecheliolide
MICHELIOLIDE

Biological Activity

[Description]:

Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others
Natural Products >> Terpenoids and Glycosides

[References]

[1]. Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18(10):13061-77.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
426.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H20O3

[ Molecular Weight ]:
248.318

[ Flash Point ]:
181.8±21.5 °C

[ Exact Mass ]:
248.141251

[ PSA ]:
46.53000

[ LogP ]:
2.14

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.555

[ Storage condition ]:
-20°C

Related Compounds