DSS Crosslinker

Names

[ Name ]:
DSS Crosslinker

[Synonym ]:
1,1'-((1,8-Dioxo-1,8-octanediyl)bis(oxy))bis-2,5-pyrrolidinedione
1,1'-[(1,8-Dioxo-1,8-octanediyl)bis(oxy)]di(2,5-pyrrolidinedione)
Di(N-succinimidyl) Suberate
2,5-Pyrrolidinedione, 1,1'-((1,8-dioxo-1,8-octanediyl)bis(oxy))bis-
Disuccinimidyl octanedioate
Suberic acid bis(N-succinimidyl) ester
MFCD00049059
1,1'-[(1,8-Dioxooctane-1,8-diyl)bis(oxy)]dipyrrolidine-2,5-dione
Disuccinimidyl suberate
Suberic acid bis(N-hydroxysuccinimide ester)
2,5-Pyrrolidinedione, 1,1'-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis-

Biological Activity

[Description]:

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
513.5±60.0 °C at 760 mmHg

[ Melting Point ]:
169-170ºC

[ Molecular Formula ]:
C₁₆H₂₀N₂O₈

[ Molecular Weight ]:
368.339

[ Flash Point ]:
264.4±32.9 °C

[ Exact Mass ]:
368.121979

[ PSA ]:
127.36000

[ LogP ]:
-2.24

[ Appearance of Characters ]:
powder

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.555

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
chloroform: 50 mg/mL | Insoluble in water. Soluble in chloroform: 50 mg/mL.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29171900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.

J. Virol. 89(6) , 3256-74, (2015)

Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promoting viral gene expression at the posttranscriptional level. Using bioinformatic and bioche...

Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.

Nat. Commun. 6 , 6123, (2015)

The chaperones Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates containing alpha and beta subunits, except beta7. Here we elucid...

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.

Br. J. Pharmacol. 172(2) , 593-605, (2014)

Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic traffick...