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Dehydroeburicoic acid

Names

[ CAS No. ]:
6879-05-6

[ Name ]:
Dehydroeburicoic acid

[Synonym ]:
(R)-2-((3S,5R,10S,13R,14R,17R)-3-Hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methylene-heptanoic acid
3β-Hydroxy-eburica-7,9(11),24(28)-trien-21-saeure
dehydroeburicoic acid
3β-Hydroxy-24-methylen-lanosta-7,9(11)-dien-21-saeure
3β-hydroxy-eburica-7,9(11),24(28)-trien-21-oic acid

Biological Activity

[Description]:

Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology

[Target]

Caspase-3


[In Vivo]

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed cells with a GI50 value of 40 μM[1].

[References]

[1]. Kang HM, et al. Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway. Life Sci. 2006 Jan 2;78(6):607-13.

Chemical & Physical Properties

[ Density]:
1.07±0.1 g/cm3

[ Molecular Formula ]:
C31H48O3

[ Molecular Weight ]:
468.71100

[ Exact Mass ]:
468.36000

[ PSA ]:
57.53000

[ LogP ]:
7.56580

[ Water Solubility ]:
Insuluble (6.1E-6 g/L) (25 ºC)

Related Compounds