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CAY 10465

Names

[ CAS No. ]:
688348-33-6

[ Name ]:
CAY 10465

[Synonym ]:
1,3-Dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]vinyl}benzene
1,3-dichloro-5-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}benzene
Benzene, 1,3-dichloro-5-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-

Biological Activity

[Description]:

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
Research Areas >> Cardiovascular Disease

[Target]

Ki: 0.2 nM (AhR)[1]


[In Vitro]

CAY 10465 (Compound 4i) is a selective and high-affinity AhR receptor agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM)[1]. CAY 10465 (0.01 nM-100 μM) reduces apolipoprotein A-I (apo A-I) levels in HepG2 cells, and inhibits the synthesis of the protein[2].

[References]

[1]. de Medina P, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91.

[2]. Naem E, et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9.


[Related Small Molecules]

Pifithrin-α hydrobromide | StemRegenin 1 (SR1) | FICZ | L-Kynurenine | ITE | Diosmin | PDM 2 | Indole-3-carbinol | Mivotilate | 1,4-Chrysenequinone | Benvitimod (Tapinarof)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
361.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H9Cl2F3

[ Molecular Weight ]:
317.133

[ Flash Point ]:
201.8±21.3 °C

[ Exact Mass ]:
316.003326

[ LogP ]:
7.01

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
2-8℃

Related Compounds