Amino-PEG4-C2-amine

Names

[ CAS No. ]:
68960-97-4

[ Name ]:
Amino-PEG4-C2-amine

[Synonym ]:
1,14-diamino-3,6,9,12-tetraoxatetradecane
3,6,9,12-Tetraoxatetradecane-1,14-diamine

Biological Activity

[Description]:

Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Boiling Point ]:
139 °C/0.2 mmHg

[ Molecular Formula ]:
C₁₀H₂₄N₂O₄

[ Molecular Weight ]:
236.30900

[ Flash Point ]:
157 °C

[ Exact Mass ]:
236.17400

[ PSA ]:
88.96000

[ LogP ]:
0.37080

[ Index of Refraction ]:
1.47

Safety Information

[ Hazard Class ]:
8.0

Amino-PEG4-C2-amine

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds