Succinaldehydic acid

Names

[ CAS No. ]:
692-29-5

[ Name ]:
Succinaldehydic acid

[Synonym ]:
MFCD00010579
3-Formylpropanoic acid
Succinic acid semialdehyde
Butanoic acid, 4-oxo-
4-Oxobutanoic acid
3-Formylpropionic acid
Butryaldehydic acid
4-Oxobutyric acid
Succinic semialdehyde
Succinaldehydic acid
Succinic semialdehyde monomer

Biological Activity

[Description]:

Succinaldehydic acid is a catabolite of GABA.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vitro]

Succinaldehydic acid (Succinic semialdehyde) is a catabolite of GABA, which is catabolized in the mitochondrial matrix through the GABA shunt, encompassing transamination to Succinaldehydic acid followed by oxidation to succinate by the concerted actions of GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), respectively[1].

[References]

[1]. Ravasz D, et al. Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int. 2017 Oct;109:41-53.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
248.6±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₆O₃

[ Molecular Weight ]:
102.089

[ Flash Point ]:
118.4±19.1 °C

[ Exact Mass ]:
102.031693

[ PSA ]:
54.37000

[ LogP ]:
-0.35

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.430

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM3380000

CHEMICAL NAME :: Succinaldehydic acid

CAS REGISTRY NUMBER :: 692-29-5

BEILSTEIN REFERENCE NO. :: 1745187

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H6-O3

MOLECULAR WEIGHT :: 102.10

WISWESSER LINE NOTATION :: VH2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 3,697,1969

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M

Safety Information

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%