γ-Caprolactone

Names

[ CAS No. ]:
695-06-7

[ Name ]:
γ-Caprolactone

[Synonym ]:
4-Hexanolide
γ-Ethyl-γ-butyrolactone
gamma-Hexanolactone
5-Ethyldihydrofuran-2(3H)-one
gamma-caprolactone
5-Ethyldihydrofuran-2(3H)-on
2(3H)-Furanone, 5-ethyldihydro-
5-Ethyldihydro-2(3H)-furanone
MFCD00005401
g-Caprolactone
EINECS 211-778-8

Biological Activity

[Description]:

γ-Hexalactone is a gamma-lactone found in ripe fruits. γ-Hexalactone can induce DNA damage, acts a substrate of Paraoxonase 1 (PON1)[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. E-Nose and GC-MS Reveal a Difference in the Volatile Profiles of White- and Red-Fleshed Peach Fruit. Sensors (Basel). 2018 Mar 2;18(3).

[2]. Bianchi T, et al. Investigation of the aroma of commercial peach (Prunus persica L. Batsch) types by Proton Transfer Reaction-Mass Spectrometry (PTR-MS) and sensory analysis. Food Res Int. 2017 Sep;99(Pt 1):133-146.

[3]. Shangula S, et al. PON1 increases cellular DNA damage by lactone substrates. Arch Toxicol. 2019 Jul;93(7):2035-2043.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
214.9±8.0 °C at 760 mmHg

[ Melting Point ]:
-18°C

[ Molecular Formula ]:
C₆H₁₀O₂

[ Molecular Weight ]:
114.142

[ Flash Point ]:
98.3±0.0 °C

[ Exact Mass ]:
114.068077

[ PSA ]:
26.30000

[ LogP ]:
0.26

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.432

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU4220000

CHEMICAL NAME :: 2(3H)-Furanone, 5-ethyldihydro-

CAS REGISTRY NUMBER :: 695-06-7

BEILSTEIN REFERENCE NO. :: 0107260

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H10-O2

MOLECULAR WEIGHT :: 114.16

WISWESSER LINE NOTATION :: T5OVTJ E2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,791,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6862 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
LU4220000

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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