2H-1-Benzopyran-4-aceticacid, 7-hydroxy-2-oxo-

Names

[ Name ]:
2H-1-Benzopyran-4-aceticacid, 7-hydroxy-2-oxo-

[Synonym ]:
7-HYDROXY-4-COUMARINYLACETIC ACID,FOR F LUORESCENCE
B-UMBELLIFERONE ACETIC ACID
2-(7-hydroxy-2-oxochromen-4-yl)acetic acid
7-HYDROXYCOUMARINYL-4-ACETIC ACID
UMBELLIFERONE-4-ACETIC ACID
7-hydroxy-4-coumarinyl-acetic acid
MFCD00037563
4-(CARBOXYMETHYL)UMBELLIFERONE
7-hydroxy-4-carboxymethyl-2H-benzopyran-2-one
7-Hydroxy-2-oxo-2H-1-benzopyran-4-acetic Acid
7-hydroxy-2H-chromen-2-one-4-acetic acid
7-hydroxylcoumarinyl-4-acetic acid
7-hydroxy-2-oxo-2H-1-benzopyran-4-ylacetic acid

Biological Activity

[Description]:

7-Hydroxycoumarin-4-acetic acid, a pH-indicator dye, is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Umek T, et al. Oligonucleotide Binding to Non-B-DNA in MYC. Molecules. 2019 Mar 12;24(5):1000.

Chemical & Physical Properties

[ Density]:
1.511 g/cm3

[ Boiling Point ]:
523.5ºC at 760 mmHg

[ Melting Point ]:
212 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₁H₈O₅

[ Molecular Weight ]:
220.17800

[ Flash Point ]:
214.5ºC

[ Exact Mass ]:
220.03700

[ PSA ]:
87.74000

[ LogP ]:
1.12570

[ Water Solubility ]:
DMF: soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

DNA-Linked Enzyme-Coupled Assay for Probing Glucosyltransferase Specificity.

ACS Synth. Biol. 4 , 833-41, (2015)

Traditional enzyme characterization methods are low-throughput and therefore limit engineering efforts in synthetic biology and biotechnology. Here, we propose a DNA-linked enzyme-coupled assay (DLEnC...

Towards a Second Generation of Ionic Liquid Matrices (ILMs) for MALDI-MS of Peptides, Proteins, and Carbohydrates

J. Am. Soc. Mass Spectrom. 20 , 1790-1800, (2009)

Second generation ionic liquid matrices are developed, examined, and tested. They have shown a wide mass detection range (<1000 Da to >270,000 Da) for proteins and peptides with greater S/N ratios tha...

Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes.

Bioorg. Med. Chem. Lett. 20(20) , 5994-6, (2010)

In continued efforts to develop enzymatic assays for lysosomal storage diseases appropriate for newborn screening laboratories we have synthesized novel and specific enzyme substrates for Maroteaux-La...