Thymopentin

Names

[ Name ]:
Thymopentin

[Synonym ]:
L-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-α-aspartyl)-L-valyl)-
TP-5
RKDVY
THYMOPENTIN 5
Thymopentin
Arg-Lys-Asp-Val-Tyr
thymopoietin
MFCD00214200
N-[N-[N-(N2-L-Arginyl-L-lysyl)-L-a-aspartyl]-L-valyl]-L-tyrosine
THYMOPETIN
L-Arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
L-Tyrosine, L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-
thymopoietin fragment 32-36
Timunox
HArgLysAspValTyrOH
Immunox
N-(diaminomethylidene)-L-ornithyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
Thymopoietin 32-36
THYMOPOIETIN PENTAPEPTIDE
Sintomodulina

Biological Activity

[Description]:

Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Thymopentin enhances the generation of T-cell lineage derived from hESCs in vitro [1].

[References]

[1]. Zhu MX, et al. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells in vitro. Exp Cell Res. 2015 Feb 15;331(2):387-98.

[2]. Lin S, et al. Novel strategy for immunomodulation: Dissolving microneedle array encapsulating thymopentin fabricated by modified two-step molding technology. Eur J Pharm Biopharm. 2018 Jan;122:104-112.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₃₀H₄₉N₉O₉

[ Molecular Weight ]:
679.765

[ Exact Mass ]:
679.365295

[ PSA ]:
325.17000

[ LogP ]:
-0.89

[ Index of Refraction ]:
1.636

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process.

Int. J. Pharm. 427(2) , 385-92, (2012)

The objective of this study was to investigate the stability and aerosolization of pressurized metered dose inhalers (pMDIs) containing thymopentin nanoparticles. Thymopentin nanoparticles, fabricated...

Separation and purification of thymopentin with molecular imprinting membrane by solid phase extraction disks.

J. Pharm. Biomed. Anal. 102 , 137-43, (2014)

The synthesis and performance of molecularly imprinted membranes (MIMs) as a solid phase extraction packing materials for the separation and purification of thymopentin from crude samples was describe...

[Vulvar lesions caused by Papillomavirus (HPV): effectiveness of thymopentin (Syntomoduline). First results and experiences].

Minerva Ginecol. 43(1-2) , 53-6, (1991)

The study included two different sized groups of patients suffering from various degrees of valvular microcondylomatosis. A group of 40 patients was treated using combined therapy while a second group...