Benzaldehyde,3-chloro-, 2-[(3-chlorophenyl)methylene]hydrazone

Names

[ Name ]:
Benzaldehyde,3-chloro-, 2-[(3-chlorophenyl)methylene]hydrazone

[Synonym ]:
Benzaldehyde,m-chloro-,azine
3,3'-Dichlor-benzaldorzin
3.3'-Dichlor-benzaldazin
3,3'-DICHLOROBENZALDAZINE
3,3'-Dichlorobenzylideneazine

Biological Activity

[Description]:

DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of themetabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5) . DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR 5

[References]

[1]. O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64(3):731-40.

Chemical & Physical Properties

[ Density]:
1.21g/cm3

[ Boiling Point ]:
387.794ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₀Cl₂N₂

[ Molecular Weight ]:
277.14900

[ Flash Point ]:
188.331ºC

[ Exact Mass ]:
276.02200

[ PSA ]:
24.72000

[ LogP ]:
4.44640

[ Index of Refraction ]:
1.59

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H317-H318-H335-H410

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-37/38-41-43-50/53

[ Safety Phrases ]:
26-36/37-60-61

[ RIDADR ]:
UN 3077 9/PG 3

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