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ZIO 101

Names

[ CAS No. ]:
69819-86-9

[ Name ]:
ZIO 101

[Synonym ]:
Darinaparsin
ZIO-101-C
UNII-9XX54M675G
Zinapar
SGLU1
ZIO-101
SP-02L
Darinaparsin (USAN)
DMAs(III)G

Biological Activity

[Description]:

Darinaparsin (ZIO-101), an organic arsenical, is a mitochondrial-targeted agent. Darinaparsin induces apoptosis in ancer cells, and has anticancer effects[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Darinaparsin is cytotoxic to prostate cancer cell lines as well as fresh prostate cancer cells at low micromolar concentrations, and importantly inhibits the termed tumor-initiating cells (TIC) subpopulations[1].

[In Vivo]

Darinaparsin inhibits growth of the castrate-resistant Du145 prostate tumor propagated as xenograft in mice and inhibits the tumor-initiating potential of prostate cancer cells[1].

[References]

[1]. Nitu Bansal, et al. Darinaparsin inhibits prostate tumor-initiating cells and Du145 xenografts and is an inhibitor of hedgehog signaling. Mol Cancer Ther. 2015 Jan;14(1):23-30.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H22AsN3O6S

[ Molecular Weight ]:
411.30600

[ Exact Mass ]:
411.04500

[ PSA ]:
191.10000

[ LogP ]:
1.22930

Related Compounds