84-B10

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin (HY-17394) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI)[1].

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Ferroptosis

84-B10 (10-100 μM; 2 h) 以剂量依赖性方式抑制顺铂诱导的肾小管上皮细胞铁死亡[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 恢复顺铂诱导的线粒体结构损伤和功能障碍[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 减轻顺铂诱导的 AKI 中 mtROS 诱导的氧化应激[1]。 84-B10 (40 μM; 2 小时; TKPT 细胞) 通过消除 mtROS 和恢复线粒体稳态来减轻顺铂诱导的上皮细胞损伤[1]。 Western Blot Analysis[1] Cell Line: tubular epithelial cell Concentration: 10, 20, 30, 40, 50, and 100 μM Incubation Time: 2 hours Result: Increased the levels of NRF2, SLC7A11, and GPX4 in a dose-dependent manner. Western Blot Analysis[1] Cell Line: TKPT cells Concentration: 40 μM Incubation Time: 2 hours Result: Increased the levels of OM Porins, IMS Cyt c, IM CVa, IM Core 1, and Matrix CypD in a dose-dependent manner.

84-B10 (5-15 mg/kg; i.p.) 减轻顺铂诱导的小鼠急性肾损伤[1]。 Animal Model: Male C57BL/6 mice with acute kidney injury[1] Dosage: 5, 10, and 15 mg/kg Administration: intraperitoneal injection Result: Decreased the sCr and BUN levels of cisplatin-exposed mice. Attenuated renal tubules morphological abnormalities in a dose-dependent manner. Decreased NGAL and KIM-1 levels in a dose-dependent manner. Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.

[1]. Fan J, et, al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free Radic Biol Med. 2023 Jan;194:84-98.