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Evodine

Names

[ CAS No. ]:
6989-38-4

[ Name ]:
Evodine

[Synonym ]:
1-[(4,8-Dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-3-buten-2-ol
3-Buten-2-ol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-
(-)-1'-(2-phenylethylene)-ditryptophenaline
(-)-1-(4,8-dimethoxy-furo[2,3-b]quinolin-7-yloxy)-3-methyl-but-3-en-2-ol
Evodine

Biological Activity

[Description]:

Evodine, the major limonoid of Evodiae Fuctus, is a potent P-gp inhibitor. Evodine has protection against glutamateinduced toxicity by preserving the antioxidant defense system[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Xia YY, et al. Simultaneous determination of evodiamine and evodine in Beagle dog plasma using liquidchromatography tandem mass spectrometry. J Asian Nat Prod Res. 2013;15(3):235-43.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
507.0±50.0 °C at 760 mmHg

[ Melting Point ]:
153-154ºC

[ Molecular Formula ]:
C18H19NO5

[ Molecular Weight ]:
329.347

[ Flash Point ]:
260.4±30.1 °C

[ Exact Mass ]:
329.126312

[ PSA ]:
73.95000

[ LogP ]:
3.26

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
2-8C

Related Compounds