Pimonidazole hydrochloride

Names

[ Name ]:
Pimonidazole hydrochloride

[Synonym ]:
Ro 03-8799
Pimonidazole hydrochloride
1-(2-nitro-1h-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol hydrochloride(1:1)
Pimonidazole HCl

Biological Activity

[Description]:

Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.

[2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.

Chemical & Physical Properties

[ Boiling Point ]:
490.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₉ClN₄O₃

[ Molecular Weight ]:
290.74700

[ Flash Point ]:
250.5ºC

[ Exact Mass ]:
290.11500

[ PSA ]:
87.11000

[ LogP ]:
1.90120

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM9465000

CHEMICAL NAME :: 1-Piperidineethanol, alpha-((2-nitro-1H-imidazol-1-yl)methyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 70132-51-3

LAST UPDATED :: 198709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H18-N4-O3.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IOBPD3 International Journal of Radiation Oncology, Biology, Physics. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1975- Volume(issue)/page/year: 12,1097,1986