2',3'-Dihydroxy-4'-methoxyacetophenone

Names

[ CAS No. ]:
708-53-2

[ Name ]:
2',3'-Dihydroxy-4'-methoxyacetophenone

[Synonym ]:
2,3-Dihydroxy-4-methoxy-acetophenon
Gallacetophenone-4'-methyl Ether
2,3-dihydroxy-4-methoxyacetophenone
1-acetyl-2,3-dihydroxy-4-methoxybenzene
Ethanone, 1-(2,3-dihydroxy-4-methoxyphenyl)-
MFCD00180772
1-(2,3-Dihydroxy-4-methoxyphenyl)ethanone
1-(2,3-DIHYDROXY-4-METHOXYPHENYL)-ETHANONE

Biological Activity

[Description]:

2,3-Dihydroxy-4-methoxyacetophenone is a neuroprotective compound from Cynenchum paniculatum. 2,3-Dihydroxy-4-methoxyacetophenone improves cognitive function and may has the potential for the treatment of Alzheimer's disease research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

2,3-Dihydroxy-4-methoxyacetophenone protects HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50=10.94 μM). 2,3-Dihydroxy-4-methoxyacetophenone inhibits [Ca2+] accumulation in HT22 cells and has antioxidantive activity[1].

[In Vivo]

2,3-dihydroxy-4-methoxyacetophenone (50mg/kg; po) improves the impairment of spatial memory induced by scopolamine[1].

[References]

[1]. Jin Bae Weon, et al. The Ameliorating Effects of 2,3-dihydroxy-4-methoxyacetophenone on Scopolamine-Induced Memory Impairment in Mice and Its Neuroprotective Activity. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6732-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
359.6±42.0 °C at 760 mmHg

[ Melting Point ]:
133ºC

[ Molecular Formula ]:
C₉H₁₀O₄

[ Molecular Weight ]:
182.173

[ Flash Point ]:
147.7±21.4 °C

[ Exact Mass ]:
182.057907

[ PSA ]:
66.76000

[ LogP ]:
1.81

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.573

MSDS

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Safety Information

[ HS Code ]:
2914509090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%