Chloramine-T trihydrate

Names

[ Name ]:
Chloramine-T trihydrate

[Synonym ]:
N-chloro-toluene-4-sulfonamide,sodium salt
Chloramine-T trihydrate
MFCD00149066
TOSYLCHLORAMIDE SODIUM TRIHYDRATE
ChloraMine T&chloroamine T trihydrate
sodium chloro[(4-methylphenyl)sulfonyl]azanide trihydrate
CHLORAMINE T GR
CHLORAMINE T 3-HYDRATE
CHLORAMINE T TRIHYDRATE
N-Chloro-p-toluenesulfonamide sodium salt trihydrate
chloramine T hydratee
CHLOROMINE-T SOLUTION
Sodium chloro[(4-methylphenyl)sulfonyl]azanide hydrate (1:1:3)
Chloroamine t trihydrate
Benzenesulfonamide, N-chloro-4-methyl-, sodium salt, hydrate (1:1:3)
CHLOROAMINUM
Chloramine-T,Sodium salt
EINECS 204-854-7

Biological Activity

[Description]:

Tosylchloramide sodium trihydrate (Chloramine T sodium trihydrate) is a disinfectant agent widely used in laboratories, kitchens and hospitals. It is also used as a biocide in air fresheners and deodorants.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[In Vitro]

Gram-positive growth is reduced by 95% to 100% after tosylchloramide treatment, regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition[1].

[In Vivo]

A dose-dependently significant DNA damage in the rat tissues and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats[2]. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress[3]. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day[4].

[Animal admin]

Rats: Male and female groups of rats are exposed to tosylchloramide at concentrations of 0.2, 0.9 and 4 mg/m3 for 6 hr/day, 5 days/week during 4 weeks. All rats are sacrificed after treatment for 4 weeks[2].

[References]

[1]. Kloth LC, et al. Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro. Adv Skin Wound Care. 2007 Jun;20(6):331-45.

[2]. Shim I, et al. Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats. J Toxicol Sci. 2013;38(6):937-46.

[3]. Kuklina I, et al. Investigation of chloramine-T impact on crayfish Astacus leptodactylus (Esch., 1823) cardiac activity. Environ Sci Pollut Res Int. 2014 Sep;21(17):10262-9.

[4]. Martínez MA, et al. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91.

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
167-170 °C(lit.)

[ Molecular Formula ]:
C₇H₁₃ClNNaO₅S

[ Molecular Weight ]:
281.690

[ Flash Point ]:
92 °C

[ Exact Mass ]:
281.010071

[ PSA ]:
70.21000

[ LogP ]:
3.09910

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H334

[ Supplemental HS ]:
Contact with acids liberates toxic gas.

[ Precautionary Statements ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R31;R34;R42

[ Safety Phrases ]:
S22-S26-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
XT5616800

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Precursor & DownStream

Precursor

DownStream

Articles

Catalytic diastereoselective sulfimidation of diaryl sulfides and application of chiral sulfimides to asymmetric allylic alkylation.

Chirality 12(5-6) , 299-312, (2000)

The copper-catalyzed diastereoselective imidation of diaryl sulfides bearing a chiral oxazolinyl moiety at the ortho-position with [N-(p-toluenesulfonyl) imino]phenyliodinane (TsN=IPh) or Chloramine-T...

The estimation of microgram amounts of methionine by reaction with chloramine-T.

Anal. Biochem. 93 , 419, (1979)

THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Biochem. J. 89 , 114, (1963)