Oxyphenbutazone monohydrate

Names

[ Name ]:
Oxyphenbutazone monohydrate

[Synonym ]:
oxyphenbutazon monohydrate
OXYPHENBUTAZONE HYDRATE
OXYPHENBUTAZONE MONOHYDRATE
OXYPHENYL BUTAZONE MONOHYDRATE
Unii-H806S4B3ns

Biological Activity

[Description]:

Oxyphenbutazone monohydrate is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone monohydrate is an orally active non-selective COX inhibitor. Oxyphenbutazone monohydrate selectively kills non-replicating Mycobaterium tuberculosis[1][2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

COX, Bacteria[1][2]

[In Vitro]

Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells[1]. Oxyphenbutazone (2.5-7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells[1]. Oxyphenbutazone exhibits reparative effects in the hepatocytes[1]. Cell Viability Assay[1] Cell Line: Hep3B cells Concentration: 2.5 µM, 5 µM, 7.5 µM Incubation Time: 48 hours Result: Enhanced the cytotoxicity of MTX.

[In Vivo]

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.)[1]. Animal Model: Wistar strain albino male rats (5-6 weeks; 150-220 g)[1] Dosage: 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration: PO; once a week; in two divided doses; for 13 weeks Result: Exerted potential anticancer activity in rats when co-treatment with MTX.

[References]

[1]. Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444(1-2):187-196.

[2]. Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16004-11.

Chemical & Physical Properties

[ Boiling Point ]:
485.6ºC at 760 mmHg

[ Melting Point ]:
96°; mp 124-125°

[ Molecular Formula ]:
C₁₉H₂₂N₂O₄

[ Molecular Weight ]:
342.38900

[ Flash Point ]:
247.5ºC

[ Exact Mass ]:
342.15800

[ PSA ]:
70.08000

[ LogP ]:
3.55910

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/38-40-42/43

[ Safety Phrases ]:
22-26-36