Pirazolac

Names

[ Name ]:
Pirazolac

[Synonym ]:
Pirazolaco
[1-(4-Fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazol-3-yl]-acetic acid
4-(4-Chlorphenyl)-1-(4-fluorphenyl)-pyrazol-3-essigsaeure
Pirazolacum
Pirazolacum [INN-Latin]
Pirazolac (USAN/INN)
PIRAZOLAC
4-(4-chlorophenyl)-1-(4-fluorophenyl)-3-pyrazolylacetic acid
Pirazolaco [INN-Spanish]

Biological Activity

[Description]:

Pirazolac is a non-steroidal anti-inflammatory drug.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Pirazolac is a non-steroidal anti-inflammatory drug. Pirazolac concentration-relatedly inhibits the accumulation of prostanoids in incubates of human gastric mucosa, but this inhibition is less than that by indomethacin and other commonly used non-steroidal anti-inflammatory drugs. This difference may explain the claim that Pirazolac is less damaging to the stomach[1].

[References]

[1]. Tavares IA, et al. Effect of pirazolac on prostanoid synthesis by human gastric mucosa in vitro. Drugs Exp Clin Res. 1990;16(1):1-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
520.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂ClFN₂O₂

[ Molecular Weight ]:
330.74100

[ Flash Point ]:
268.8ºC

[ Exact Mass ]:
330.05700

[ PSA ]:
55.12000

[ LogP ]:
3.95890

[ Index of Refraction ]:
1.629

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%