<Suppliers Price>

1-Acetyl-3-o-toluyl-5-fluorouracil

Names

[ CAS No. ]:
71861-76-2

[ Name ]:
1-Acetyl-3-o-toluyl-5-fluorouracil

[Synonym ]:
A-OT
1-Acetyl-5-fluoro-3-(2-methylbenzoyl)-2,4-(1H,3H)-pyrimidinedione
N(sub 1)-Acetyl-N(sub 3)-o-toluyl-5-fluorouracil
Atofluding
1-Acetyl-3,2-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione,1-acetyl-5-fluoro-3-(2-methylbenzoyl)
1-Acetyl-3-o-toluyl-5-fluorouracil

Biological Activity

[Description]:

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[In Vivo]

Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1].

[Animal admin]

Mice: Of the ten groups of tumor bearing mice, subcutaneous administration of 5-fluorouracil or 1-Acetyl-3-o-toluyl-5-fluorouracil is made at a dose of 0.2, 0.4 and 0.6 mmol/kg/d on six groups in the buttock region. In three groups, oil solution of 1-Acetyl-3-o-toluyl-5-fluorouracil is administered orally with a stomach tube at a dose of 0.2, 0.4 and 0.6 mmol/kg/d. The remaining group is used as tumor bearing control. During the period of the experiment, body weight is measured every 3 day and the long and short diameters of the tumor are measured daily[1].

[References]

[1]. Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.44g/cm3

[ Boiling Point ]:
408.8ºC at 760 mmHg

[ Molecular Formula ]:
C14H11FN2O4

[ Molecular Weight ]:
290.24700

[ Flash Point ]:
201.1ºC

[ Exact Mass ]:
290.07000

[ PSA ]:
78.14000

[ LogP ]:
0.80610

[ Index of Refraction ]:
1.609

[ Storage condition ]:
2-8℃

Related Compounds