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ZJ 43

Names

[ CAS No. ]:
723331-20-2

[ Name ]:
ZJ 43

[Synonym ]:
zj 43

Biological Activity

[Description]:

ZJ43 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

IC50: 2.4 nM (NAAG)[1]


[References]

[1]. Olszewski RT, et al. NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem. 2004 May;89(4):876-85.

[2]. Yamamoto T, et al. Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model. Eur J Neurosci. 2004 Jul;20(2):483-94.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H20N2O7

[ Molecular Weight ]:
304.30

[ Exact Mass ]:
304.12700

[ PSA ]:
153.03000

[ LogP ]:
0.88470

Related Compounds