oxacillin sodium monohydrate

Names

[ Name ]:
oxacillin sodium monohydrate

[Synonym ]:
MFCD00056864
sodium,(2S,5R,6R)-3,3-dimethyl-6-[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate,hydrate
Sodium (2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate (1:1:1)
Monosodium (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-4-isoxazolecarboxamido)-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate monohydrate
Oxacillin Sodium Salt Monohydrate
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-, sodium salt, (2S,5R,6R)-, hydrate (1:1:1)
EINECS 214-636-3
oxacillin sodium

Biological Activity

[Description]:

Oxacillin sodium monohydrate is an antibiotic similar to flucloxacillin used in resistant staphylococci infections.Target: AntibacterialOxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Another related compound is nafcillin. Since it is resistant to penicillinase enzymes, such as that produced by Staphylococcus aureus, it is widely used clinically in the US to treat penicillin-resistant Staphylococcus aureus. However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called oxacillin-resistant Staphylococcus aureus (MRSA/ORSA) have become increasingly prevalent worldwide. MRSA/ORSA is treated using vancomycin. From Wikipedia.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. http://en.wikipedia.org/wiki/Oxacillin

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
686.8ºC at 760 mmHg

[ Melting Point ]:
188ºC

[ Molecular Formula ]:
C₁₉H₂₀N₃NaO₆S

[ Molecular Weight ]:
441.43

[ Flash Point ]:
369.2ºC

[ PSA ]:
136.54000

[ LogP ]:
0.99210

[ Index of Refraction ]:
205 ° (C=1, H2O)

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R36/37/38;R42/43

[ Safety Phrases ]:
S22-S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
3004101900

Customs

[ HS Code ]: 3004101900

Articles

Antimicrobial/anti-biofilm activity of expired blood platelets and their released products.

Postepy. Hig. Med. Dosw. 67 , 321-5, (2013)

Although platelets are not part of the classical immune system, they have many features that indicate their role in the anti-infective host defense. They come into interactions with microorganisms, wh...

Antimicrobial susceptibility of animal and human isolates of Clostridium difficile by broth microdilution.

J. Med. Microbiol. 62(Pt 9) , 1478-85, (2013)

A total of 188 human (n = 92) and animal (n = 96) isolates of Clostridium difficile of different PCR ribotypes were screened for susceptibility to 30 antimicrobials using broth microdilution. When com...

Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius.

PLoS ONE 10 , e0130385, (2015)

Staphylococcus pseudintermedius is a commensal organism of companion animals that is a significant source of opportunistic infections in dogs. With the emergence of clinical isolates of S. pseudinterm...