Methyl-PEG3-bromide

Names

[ CAS No. ]:
72593-77-2

[ Name ]:
Methyl-PEG3-bromide

[Synonym ]:
1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane

Biological Activity

[Description]:

Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.288g/cm3

[ Boiling Point ]:
245.798ºC at 760 mmHg

[ Molecular Formula ]:
C₇H₁₅BrO₃

[ Molecular Weight ]:
227.09600

[ Flash Point ]:
96.375ºC

[ Exact Mass ]:
226.02000

[ PSA ]:
27.69000

[ LogP ]:
1.06090

[ Index of Refraction ]:
1.451

MSDS

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Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

Methyl-PEG3-bromide

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds