4-(trifluoromethyl)benzophenone

Names

[ CAS No. ]:
728-86-9

[ Name ]:
4-(trifluoromethyl)benzophenone

[Synonym ]:
fxffr dvr
Phenyl[4-(trifluoromethyl)phenyl]methanone
EINECS 211-974-3
(4-(trifluoromethyl)phenyl)(phenyl)methanone
p-Trifluoromethylbenzophenone
4-(Trifluoromethyl)benzophenone
MFCD00000400
phenyl 4-(trifluoromethyl)phenyl ketone
(4-trifluoromethyl)(phenyl)methanone

Biological Activity

[Description]:

11β-HSD1-IN-7 (compound c10a) is a 11β‑HSD1 inhibitor with an IC50 value of 1.9 μM for human 11β‑HSD1. 11β-HSD1-IN-7 can be used for the research of diabetes and cognitive decline[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

[Target]

IC50: 1.9 μM (human 11β‑HSD1)[1]

[In Vitro]

11β-HSD1-IN-7 (0-50 μM) inhibits human and rat 11β‑HSD1 with IC50 values of 1.9 μM and ＞50 μM, respectively[1].

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
309.2ºC at 760 mmHg

[ Melting Point ]:
114-116 °C(lit.)

[ Molecular Formula ]:
C₁₄H₉F₃O

[ Molecular Weight ]:
250.21600

[ Flash Point ]:
153ºC

[ Exact Mass ]:
250.06100

[ PSA ]:
17.07000

[ LogP ]:
3.93640

[ Index of Refraction ]:
1.519

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%