Eltenac

Names

[ Name ]:
Eltenac

[Synonym ]:
4-(2,6-dichloroanilino)-3-thiophenacetic acid
Telzenac (TN)
ELTENAC
Eltenaco
Eltenacum
4-(2,6-dichloroanilino)-3-thiopheneacetic acid
[4-(2,6-dichlorophenylamino)-thiophen-3-yl] acetic acid
Eltenac (INN)
Telzenac
Eltenaco [Spanish]
Eltenacum [Latin]

Biological Activity

[Description]:

Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:0.03 μM (IC50)

COX-2:0.03 μM (IC50)

[In Vitro]

Eltenac (10 mg/kg; p.o.; Female Sprague-Dawley rats weighing150-190; rat paw edema model) efficaciously reduces the increase in paw volume by 52%[1].

[References]

[1]. Klein T,, et al. Characterization of eltenac and novel COX-2 selective thiopheneacetic acid analogues in vitro and in vivo. Biochem Pharmacol. 2008;76(6):717-725.

Chemical & Physical Properties

[ Density]:
1.539g/cm3

[ Boiling Point ]:
419.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₉Cl₂NO₂S

[ Molecular Weight ]:
302.18

[ Flash Point ]:
207.4ºC

[ Exact Mass ]:
300.97300

[ PSA ]:
77.57000

[ LogP ]:
4.49860

[ Index of Refraction ]:
1.688

Safety Information

[ Hazard Codes ]:
T+

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%