Psoromic Acid
Names
Biological Activity
[Description]:
Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 µM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2].
[Related Catalog]:
[Target]
IC50: 1.3 µM (RabGGTase)[1]
[References]
Chemical & Physical Properties
[ Density]:
1.483 g/cm3
[ Boiling Point ]:
641.7ºC at 760 mmHg
[ Molecular Formula ]:
C18H14O8
[ Molecular Weight ]:
358.30
[ Flash Point ]:
237ºC
[ Exact Mass ]:
358.06900
[ PSA ]:
119.36000
[ LogP ]:
2.85320
[ Index of Refraction ]:
1.658
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP3082200
- CHEMICAL NAME :
- 11H-Dibenzo(b,e)(1,4)dioxepin-6-carboxylic acid, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl- 11-oxo-
- CAS REGISTRY NUMBER :
- 7299-11-8
- LAST UPDATED :
- 198308
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 9,55,1982