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Met-Enkephalin-Arg-Phe

Names

[ CAS No. ]:
73024-95-0

[ Name ]:
Met-Enkephalin-Arg-Phe

[Synonym ]:
MERF
TYR-GLY-GLY-PHE-MET-ARG-PHE
METHIONINE ENKEPHALIN-ARG,PHE
Tyr-Gly-Gly-Phe-Met-Arg-Phe-OH
Met-Enkephalin-Arg-Phe MERF

Biological Activity

[Description]:

Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vivo]

Met-Enkephalin-Arg-Phe (10-100 nmol/mouse; i.c.v.; once) 在小鼠中有缓解疼痛活性[1]。 Animal Model: Male Swiss Webster mice[1] Dosage: 10-100 nmol/mouse Administration: Intracerebralventricular injection, once Result: Produced a dose-related inhibition of the tail-flick response. The effects peaked at 2-4 min and were dissipated by 10 min. The EC50 was 38.5 nmol/mouse.

[References]

[1]. Inturrisi CE, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4.  

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C42H56N10O9S

[ Molecular Weight ]:
877.02

[ Exact Mass ]:
876.39500

[ PSA ]:
345.35000

[ LogP ]:
3.25660

[ Index of Refraction ]:
1.65

Related Compounds