3-Methyl-2-quinoxalinecarboxylic acid

Names

[ Name ]:
3-Methyl-2-quinoxalinecarboxylic acid

[Synonym ]:
3-Methyl-quinoxaline-2-carboxylic acid
2-Methyl-3-carboxy-chinoxalin
3-Methylchinoxalin-2-carbonsaeure
methylquinoxalinecarboxylicacid
3-Methyl-2-quinoxalinecarboxylic acid
3-methylquinoxaline-2-carboxylic acid
2-Quinoxalinecarboxylic acid, 3-methyl-

Biological Activity

[Description]:

3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Keyu Zhang , et al. Cytotoxicity and Genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic Acid (MQCA) in Human Hepatocytes. Res Vet Sci. 2012 Dec;93(3):1393-401.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
347.1±37.0 °C at 760 mmHg

[ Melting Point ]:
168-170ºC

[ Molecular Formula ]:
C₁₀H₈N₂O₂

[ Molecular Weight ]:
188.183

[ Flash Point ]:
163.7±26.5 °C

[ Exact Mass ]:
188.058578

[ PSA ]:
63.08000

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.673

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
22-36/37

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%