3,3',4,4'-Biphenyltetramine tetrahydrochloride

Names

[ Name ]:
3,3',4,4'-Biphenyltetramine tetrahydrochloride

[Synonym ]:
DAB TABLET
DAB SUBSTRATE
DAB-HCL
Biphenyl-3,3',4,4'-tetramine tetrahydrochloride
DAB TETRAHYDROCHLORIDE
DAB
3,3',4,4'-Biphenyltetramine tetrahydrochloride
DAB,tetrahydrochloride3
3,3`-Diaminobenzidine tetrahydrochloride
DAB EASY tablets
DAB anhydrous
MFCD00012969
[1,1'-Biphenyl]-3,3',4,4'-tetramine, hydrochloride (1:4)
DAB 4HCL
EINECS 231-018-9
DAB WITH METAL ENHANCER

Biological Activity

[Description]:

3,3'-Diaminobenzidine(DAB) is an organic compound that is both chemically and thermodynamically stable; DAB has been used in immunohistochemical staining of nucleic acids and proteins.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[References]

[1]. Hannetz Roschzttardtz, et al. Plant Cell Nucleolus as a Hot Spot for Iron.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
481.7ºC at 760 mmHg

[ Melting Point ]:
300°C

[ Molecular Formula ]:
C₁₂H₁₈Cl₄N₄

[ Molecular Weight ]:
360.110

[ Flash Point ]:
282.7ºC

[ Exact Mass ]:
358.028564

[ PSA ]:
104.08000

[ LogP ]:
7.21520

[ Water Solubility ]:
Soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV8753000

CHEMICAL NAME :: 3,3',4,4'-Biphenyltetramine, tetrahydrochloride

CAS REGISTRY NUMBER :: 7411-49-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H14-N4.4Cl-H

MOLECULAR WEIGHT :: 360.14

WISWESSER LINE NOTATION :: ZR BZ DR CZ DZ &GH 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 520 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H319-H341-H350

[ Precautionary Statements ]:
P201-P280-P301 + P312 + P330-P305 + P351 + P338-P308 + P313-P337 + P313

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R40

[ Safety Phrases ]:
S7-S16-S24-S33-S36/37-S45-S24/25-S22

[ RIDADR ]:
UN 3316 9/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
DV8753000

[ Hazard Class ]:
9.0

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For the bioanalysis of therapeutic monoclonal antibodies in biological matrices, immunoassays--especially enzyme-linked immunosorbent assays (ELISAs)--are the most widely used techniques. Although ELI...

Color modification of diaminobenzidine (DAB) precipitation by metallic ions and its application for double immunohistochemistry.

J. Histochem. Cytochem. 30 , 1079-1082, (1982)

Three metallic ions, NiCl2, CoCl2, and CuSO4, were found to modify the color of the normally brown diaminobenzidine (DAB) reaction. The colors ranged from purplish blue (NiCl2), dark blue/bluish black...