3-Bromo-7-nitro-1H-indazole

Names

[ Name ]:
3-Bromo-7-nitro-1H-indazole

[Synonym ]:
3-bromo-7-nitro-2H-indazole
3-Bromo-7-nitro-1H-indazole
MFCD00159910
1H-Indazole, 3-bromo-7-nitro-

Biological Activity

[Description]:

3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

[Target]

nNOS[1]

[References]

[1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
437.3±25.0 °C at 760 mmHg

[ Melting Point ]:
175-185 °C

[ Molecular Formula ]:
C₇H₄BrN₃O₂

[ Molecular Weight ]:
242.030

[ Flash Point ]:
218.3±23.2 °C

[ Exact Mass ]:
240.948685

[ PSA ]:
74.50000

[ LogP ]:
2.52

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.764

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 25 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
60

[ Safety Phrases ]:
S53-S22-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function.

Neuropharmacology 86 , 273-81, (2014)

Ketamine is a non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonist of interest in neuropsychiatry. In the present studies, we examined the effects of subanesthetic, low micromolar ketamine...

Role of nitric oxide in traumatic brain injury in the rat.

J. Neurosurg. 89 , 807-818, (1998)

Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains...

7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.

Life Sci. 57 , PL131-PL135, (1995)

The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung...