3-Maleimidopropionic acid

Names

[ Name ]:
3-Maleimidopropionic acid

[Synonym ]:
BMPA
β-Maleimidopropionic acid
MFCD00043030
3-(2,5-dioxopyrrol-1-yl)propanoic acid
3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid
1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo-
3-Maleimidopropionic acid
3-Maleimidopropionicacid

Biological Activity

[Description]:

3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
382.5±25.0 °C at 760 mmHg

[ Melting Point ]:
103-106 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO₄

[ Molecular Weight ]:
169.135

[ Flash Point ]:
185.1±23.2 °C

[ Exact Mass ]:
169.037506

[ PSA ]:
74.68000

[ LogP ]:
0.04

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.565

[ Storage condition ]:
-15°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

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Dalton Trans. 44(11) , 4884-900, (2015)

Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging...

Extracellular Subunit Interactions Control Transitions between Functional States of Acid-sensing Ion Channel 1a.

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Selective and Sensitive Sensing of Flame Retardant Chemicals Through Phage Display Discovered Recognition Peptide.

Nano Lett. 15 , 7697-703, (2015)

We report a highly selective and sensitive biosensor for the detection of an environmentally toxic molecule, decabrominated diphenyl ether (DBDE), one of the most common congeners of the polybrominate...