Ivachtin

Names

[ Name ]:
Ivachtin

[Synonym ]:
2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-
IVACHTIN
Caspase-3 Inhibitor VII
HMS3269H15
2-[4-Methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate

Biological Activity

[Description]:

Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Neurological Disease

[Target]

Caspase-3:23 nM (IC50)

[In Vitro]

Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells[1].

[References]

[1]. Kravchenko DV, et al. Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. J Med Chem. 2005 Jun 2;48(11):3680-3.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
665.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₁N₃O₇S

[ Molecular Weight ]:
447.462

[ Flash Point ]:
356.0±34.3 °C

[ Exact Mass ]:
447.110016

[ PSA ]:
131.56000

[ LogP ]:
1.30

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.632

Ivachtin

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds