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Bisdionin C

Names

[ CAS No. ]:
74857-22-0

[ Name ]:
Bisdionin C

[Synonym ]:
1,3-Bis-[theobrominyl-(1)]-propan
bisdionin C
3,7,3',7'-tetramethyl-3,7,3',7'-tetrahydro-1,1'-propane-1,3-diyl-bis-purine-2,6-dione

Biological Activity

[Description]:

Bisdionin C is a potent GH18 chitinases inhibitor, with an IC50 of 0.2 μM for A. fumigatus ChiB1 (AfChiB1). Bisdionin C inhibits HCHT (human macrophage chitotriosidase) and acidic mammalian chitinase (AMCase) with IC50s of 8.3 and 3.4 μM, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

GH18 Chitinases[1]


[References]

[1]. Schüttelkopf AW, et al. Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases. ACS Med Chem Lett. 2011;2(6):428-432. Published 2011 Mar 23.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H20N8O4

[ Molecular Weight ]:
400.39200

[ Exact Mass ]:
400.16100

[ PSA ]:
123.64000

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds