Methyl L-phenylalaninate hydrochloride

Names

[ Name ]:
Methyl L-phenylalaninate hydrochloride

[Synonym ]:
L-Phenylalanine, methyl ester, hydrochloride (1:1)
Methyl L-phenylalaninate hydrochloride
EINECS 231-383-4
Phenylalanine, methyl ester, hydrochloride (1:1)
L-Phenylalanine methyl ester hydrochloride
MFCD00012489
methyl (2S)-2-amino-3-phenylpropanoate,hydrochloride
H-Phe-OMe.HCl
H-Phe-OmeHCl

Biological Activity

[Description]:

H-Phe-OMe.hydrochloride is a phenylalanine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-887.

Chemical & Physical Properties

[ Boiling Point ]:
264.2ºC at 760 mmHg

[ Melting Point ]:
156-160ºC

[ Molecular Formula ]:
C₁₀H₁₄ClNO₂

[ Molecular Weight ]:
215.677

[ Flash Point ]:
126ºC

[ Exact Mass ]:
215.071304

[ PSA ]:
52.32000

[ LogP ]:
2.23170

[ Index of Refraction ]:
38 ° (C=2， EtOH)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;C: Corrosive;

[ Risk Phrases ]:
36/37/38-34

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29224995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor.

Nat. Chem. Biol. 5 , 45-52, (2009)

Transporter-related nutrient sensors, called transceptors, mediate nutrient activation of signaling pathways through the plasma membrane. The mechanism of action of transporting and nontransporting tr...

N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.

J. Med. Chem. 53 , 2354-63, (2010)

Here we studied the capacity of N-MePhe-(N-MePhe)(3)-CONH(2), Cha-(N-MePhe)(3)-CONH(2), and 2Nal-(N-MePhe)(3)-CONH(2) to carry various drugs (cargos) in in vitro blood-brain barrier (BBB) models in or...

Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.

Blood 79(4) , 964-71, (1992)

L-leucine methyl ester (Leu-OMe), Leu-Leu-OMe, Phe-OMe, and Glu-(OMe)2 are toxic to mononuclear phagocytes (M phi) and neutrophils. In the present studies, the mechanism of this toxicity was examined....