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20-Deoxyingenol 3-angelate

Names

[ CAS No. ]:
75567-38-3

[ Name ]:
20-Deoxyingenol 3-angelate

[Synonym ]:
2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-1,1,4,7,9-pentamethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-
(1S,4S,5S,6R,9S,10R,12R,14R)-5,6-Dihydroxy-3,7,11,11,14-pentamethyl-15-oxotetracyclo[7.5.1.0.0]pentadeca-2,7-dien-4-yl (2Z)-2-methyl-2-butenoate

Biological Activity

[Description]:

20-Deoxyingenol 3-angelate (DI3A) increases degranulation and interferon-gamma secretion of NK cells. 20-Deoxyingenol 3-angelate enhances NK cell tumoricidal activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Zihang Xu, et al. A high-throughput assay for screening natural products that boost NK cell-mediated killing of cancer cells. Pharm Biol. 2020, 58, 1.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
531.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H34O5

[ Molecular Weight ]:
414.534

[ Flash Point ]:
174.1±23.6 °C

[ Exact Mass ]:
414.240631

[ PSA ]:
83.83000

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.578

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds