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Artemotil

Names

[ CAS No. ]:
75887-54-6

[ Name ]:
Artemotil

[Synonym ]:
SM-227
β-arteether
Areether
(4S,5R,8S,9R,10S,12R,13R)-10-Ethoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0.0]hexadecane
Artemotil
SM-22
ARPRINOCID
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, 10-ethoxydecahydro-3,6,9-trimethyl-, (5aS,6R,8aS,9R,10S,12R,12aR)-
dihydroartemisinin ethyl ether
Unii-xgl7gfb9yi
dihydroqinghaosu ethyl ether

Biological Activity

[Description]:

Artemotil (β-Arteether) is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. Target:Artemotil is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant Artemisia annua.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite
Research Areas >> Infection

[References]

[1]. Looareesuwan S, et al. Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. Br J Clin Pharmacol. 2002 May;53(5):492-500.


[Related Small Molecules]

Hydroxychloroquine sulfate | Metronidazole | Emetine dihydrochloride hydrate | Ivermectin | Artemisinin | Levamisole (hydrochloride) | Fluralaner | RRx-001 | Avermectin | Quinidine | Bithionol | Flubendazole | Mebendazole | SQ109 | Artemether

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
372.4±42.0 °C at 760 mmHg

[ Melting Point ]:
80-820ºC

[ Molecular Formula ]:
C17H28O5

[ Molecular Weight ]:
312.401

[ Flash Point ]:
146.0±27.8 °C

[ Exact Mass ]:
312.193665

[ PSA ]:
46.15000

[ LogP ]:
3.60

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.516

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds