norastemizole

Names

[ Name ]:
norastemizole

[Synonym ]:
T 1348
Tetemizole
Soltara
Norastemizole

Biological Activity

[Description]:

Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
519.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₁FN₄

[ Molecular Weight ]:
324.40

[ Flash Point ]:
268.2ºC

[ Exact Mass ]:
324.17500

[ PSA ]:
45.11000

[ LogP ]:
3.13830

[ Index of Refraction ]:
1.658

[ Storage condition ]:
2-8°C

norastemizole

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds