1-Dehydro-6-gingerdione

Names

[ Name ]:
1-Dehydro-6-gingerdione

[Synonym ]:
1-Decene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-
1-(4-Hydroxy-3-methoxyphenyl)-1-decene-3,5-dione
[6]-Dehydrogingerdione
1-Dehydro-6-gingerdione

Biological Activity

[Description]:

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways[1]. 6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation[1]. 6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway[1]. Apoptosis Analysis[1] Cell Line: Hep G2 cells. Concentration: 0, 50, 100 μM. Incubation Time: 24 h. Result: Induced Apoptosis in Hep G2 Cells.

[References]

[1]. Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
448.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₂O₄

[ Molecular Weight ]:
290.35400

[ Flash Point ]:
159.3±20.8 °C

[ Exact Mass ]:
290.15200

[ PSA ]:
63.60000

[ LogP ]:
3.52260

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.546

1-Dehydro-6-gingerdione

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds