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Mal-PEG1-acid

Names

[ CAS No. ]:
760952-64-5

[ Name ]:
Mal-PEG1-acid

[Synonym ]:
3-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoic acid
MFCD24497443
Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-

Biological Activity

[Description]:

Mal-PEG1-acid is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9(8):838-842.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
419.4±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H11NO5

[ Molecular Weight ]:
213.187

[ Flash Point ]:
207.5±24.6 °C

[ Exact Mass ]:
213.063721

[ LogP ]:
-0.37

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.541

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds