DL-AP5

Names

[ Name ]:
DL-AP5

[Synonym ]:
UNII:39PJ29YY8Z
DL-2-amino-5-phosphonovaleric acid
D-2-amino-5-phosphonovaleric acid
APV
AP-5
DL-AP5
DL-APV
5-Phosphononorvaline
MFCD00010515
2-amino-5-phosphopentanoicacid
2-amino-5-phosphonovaleric acid
Norvaline, 5-phosphono-
5-PHOSPHONO-DL-NORVALINE
2-amino-5-phosphovaleric acid

Biological Activity

[Description]:

DL-AP5 is a NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Murray CW, Cowan A, Larson AA. Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. Pain. 1991;44(2):179-185.

[2]. Massey SC, Miller RF. N-methyl-D-aspartate receptors of ganglion cells in rabbit retina. J Neurophysiol. 1990;63(1):16-30.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
482.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₁₂NO₅P

[ Molecular Weight ]:
197.13

[ Flash Point ]:
245.4±31.5 °C

[ Exact Mass ]:
197.045303

[ PSA ]:
130.66000

[ LogP ]:
-2.32

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.536

[ Storage condition ]:
Store at RT

[ Water Solubility ]:
NH4OH 1 M: 50 mg/mL, clear, colorless

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2931900090

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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