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(6aS,11bR)-6a,11b-Dihydro-5,6a,9-trihydroxy-2,2-dimethyl-11b-(3-methyl-2-butenyl)-2H,6H-benzofuro[3,2-b]pyrano[3,2-g][1]benzopyran-6-one

Names

[ CAS No. ]:
76464-71-6

[ Name ]:
(6aS,11bR)-6a,11b-Dihydro-5,6a,9-trihydroxy-2,2-dimethyl-11b-(3-methyl-2-butenyl)-2H,6H-benzofuro[3,2-b]pyrano[3,2-g][1]benzopyran-6-one

Biological Activity

[Description]:

Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[Target]

NF-κB


[References]

[1]. Wonmin Ko, et al. Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells. Molecules. 2021 Dec 16;26(24):7642.  

Chemical & Physical Properties

[ Density]:
1.397g/cm3

[ Boiling Point ]:
668.8ºC at 760 mmHg

[ Molecular Formula ]:
C25H24O7

[ Molecular Weight ]:
436.45

[ Flash Point ]:
231.6ºC

[ Exact Mass ]:
436.15200

[ PSA ]:
105.45000

[ LogP ]:
4.18990

[ Index of Refraction ]:
1.66

Related Compounds